BDBM28953 (2S)-N-(4-chlorophenyl)-1-hydroxy-3,3-dimethylbutane-2-sulfonamido::phenylsulfonamide, 8d

SMILES: CC(C)(C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)cc1

InChI Key: InChIKey=GAVZPZUJCRTQNY-LLVKDONJSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28953   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1 (Homo sapiens (Human))	BDBM28953 ((2S)-N-(4-chlorophenyl)-1-hydroxy-3,3-dimethylbuta...) Show SMILES CC(C)(C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C12H18ClNO3S/c1-12(2,3)11(8-15)14-18(16,17)10-6-4-9(13)5-7-10/h4-7,11,14-15H,8H2,1-3H3/t11-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.91E+4	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ...				Bioorg Med Chem Lett 18: 4232-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM
					More data for this Ligand-Target Pair