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SMILES: O=C(CN1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1)N1CCCC1

InChI Key: InChIKey=DAJIYBFYMONJCT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289985   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM289985
PNG
(2-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-ben...)
Show SMILES O=C(CN1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1)N1CCCC1
Show InChI InChI=1S/C27H30N6O3/c34-27(33-9-1-2-10-33)18-32-13-11-31(12-14-32)17-21-19-35-25-15-22(4-5-23(21)25)36-26-6-3-20(16-28-26)24-7-8-29-30-24/h3-8,15-16,19H,1-2,9-14,17-18H2,(H,29,30)
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PC cid
PC sid
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US Patent
n/an/a 0.680n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...

US Patent US9573957 (2017)


BindingDB Entry DOI: 10.7270/Q27S7QTT
More data for this
Ligand-Target Pair