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SMILES: Cn1ccnc1CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O

InChI Key: InChIKey=QYTBWEJMHPQCLS-GWCFXTLKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 290395   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arginase-1 (Homo sapiens (Human))	BDBM290395 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((1-methyl-1H...) Show SMILES Cn1ccnc1CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r| Show InChI InChI=1S/C13H23BN4O4/c1-17-6-5-16-11(17)8-18-7-10(3-2-4-14(21)22)13(15,9-18)12(19)20/h5-6,10,21-22H,2-4,7-9,15H2,1H3,(H,19,20)/t10-,13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<250	n/a	n/a	n/a	n/a	7.4	25
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10098902 (2018) BindingDB Entry DOI: 10.7270/Q2319XXK
					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM290395 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((1-methyl-1H...) Show SMILES Cn1ccnc1CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r| Show InChI InChI=1S/C13H23BN4O4/c1-17-6-5-16-11(17)8-18-7-10(3-2-4-14(21)22)13(15,9-18)12(19)20/h5-6,10,21-22H,2-4,7-9,15H2,1H3,(H,19,20)/t10-,13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	625	n/a	n/a	n/a	n/a	7.4	25
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10098902 (2018) BindingDB Entry DOI: 10.7270/Q2319XXK
					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM290395 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((1-methyl-1H...) Show SMILES Cn1ccnc1CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r| Show InChI InChI=1S/C13H23BN4O4/c1-17-6-5-16-11(17)8-18-7-10(3-2-4-14(21)22)13(15,9-18)12(19)20/h5-6,10,21-22H,2-4,7-9,15H2,1H3,(H,19,20)/t10-,13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10603330 (2020)
					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	US11389464, Example 31 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((1-methyl-1H...) Show SMILES Cn1ccnc1CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r| Show InChI InChI=1S/C13H23BN4O4/c1-17-6-5-16-11(17)8-18-7-10(3-2-4-14(21)22)13(15,9-18)12(19)20/h5-6,10,21-22H,2-4,7-9,15H2,1H3,(H,19,20)/t10-,13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	625	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM290395 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((1-methyl-1H...) Show SMILES Cn1ccnc1CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r| Show InChI InChI=1S/C13H23BN4O4/c1-17-6-5-16-11(17)8-18-7-10(3-2-4-14(21)22)13(15,9-18)12(19)20/h5-6,10,21-22H,2-4,7-9,15H2,1H3,(H,19,20)/t10-,13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
New England Discovery Partners Curated by ChEMBL					Assay Description Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...				J Med Chem 62: 8164-8177 (2019) Article DOI: 10.1021/acs.jmedchem.9b00931
					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	US11389464, Example 31 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((1-methyl-1H...) Show SMILES Cn1ccnc1CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r| Show InChI InChI=1S/C13H23BN4O4/c1-17-6-5-16-11(17)8-18-7-10(3-2-4-14(21)22)13(15,9-18)12(19)20/h5-6,10,21-22H,2-4,7-9,15H2,1H3,(H,19,20)/t10-,13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM290395 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((1-methyl-1H...) Show SMILES Cn1ccnc1CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r| Show InChI InChI=1S/C13H23BN4O4/c1-17-6-5-16-11(17)8-18-7-10(3-2-4-14(21)22)13(15,9-18)12(19)20/h5-6,10,21-22H,2-4,7-9,15H2,1H3,(H,19,20)/t10-,13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10603330 (2020)
					More data for this Ligand-Target Pair