null

SMILES: N[C@]1(CN(CC2Cc3c(Cl)cc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O

InChI Key: InChIKey=LCNLEWNKLMUFMQ-PKZGSEHASA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 290423   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arginase-1 (Homo sapiens (Human))	BDBM290423 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((5,7-dichlor...) Show SMILES N[C@]1(CN(CC2Cc3c(Cl)cc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O |r| Show InChI InChI=1S/C18H26BCl2N3O4/c20-13-4-11-7-23-14(6-15(11)16(21)5-13)9-24-8-12(2-1-3-19(27)28)18(22,10-24)17(25)26/h4-5,12,14,23,27-28H,1-3,6-10,22H2,(H,25,26)/t12-,14?,18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<250	n/a	n/a	n/a	n/a	7.4	25
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10098902 (2018) BindingDB Entry DOI: 10.7270/Q2319XXK
					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM290423 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((5,7-dichlor...) Show SMILES N[C@]1(CN(CC2Cc3c(Cl)cc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O |r| Show InChI InChI=1S/C18H26BCl2N3O4/c20-13-4-11-7-23-14(6-15(11)16(21)5-13)9-24-8-12(2-1-3-19(27)28)18(22,10-24)17(25)26/h4-5,12,14,23,27-28H,1-3,6-10,22H2,(H,25,26)/t12-,14?,18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<250	n/a	n/a	n/a	n/a	7.4	25
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10098902 (2018) BindingDB Entry DOI: 10.7270/Q2319XXK
					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM290423 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((5,7-dichlor...) Show SMILES N[C@]1(CN(CC2Cc3c(Cl)cc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O |r| Show InChI InChI=1S/C18H26BCl2N3O4/c20-13-4-11-7-23-14(6-15(11)16(21)5-13)9-24-8-12(2-1-3-19(27)28)18(22,10-24)17(25)26/h4-5,12,14,23,27-28H,1-3,6-10,22H2,(H,25,26)/t12-,14?,18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM290423 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((5,7-dichlor...) Show SMILES N[C@]1(CN(CC2Cc3c(Cl)cc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O |r| Show InChI InChI=1S/C18H26BCl2N3O4/c20-13-4-11-7-23-14(6-15(11)16(21)5-13)9-24-8-12(2-1-3-19(27)28)18(22,10-24)17(25)26/h4-5,12,14,23,27-28H,1-3,6-10,22H2,(H,25,26)/t12-,14?,18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10603330 (2020)
					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM290423 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((5,7-dichlor...) Show SMILES N[C@]1(CN(CC2Cc3c(Cl)cc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O |r| Show InChI InChI=1S/C18H26BCl2N3O4/c20-13-4-11-7-23-14(6-15(11)16(21)5-13)9-24-8-12(2-1-3-19(27)28)18(22,10-24)17(25)26/h4-5,12,14,23,27-28H,1-3,6-10,22H2,(H,25,26)/t12-,14?,18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM290423 ((3R,4S)-3-amino-4-(3-boronopropyl)-1-((5,7-dichlor...) Show SMILES N[C@]1(CN(CC2Cc3c(Cl)cc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O |r| Show InChI InChI=1S/C18H26BCl2N3O4/c20-13-4-11-7-23-14(6-15(11)16(21)5-13)9-24-8-12(2-1-3-19(27)28)18(22,10-24)17(25)26/h4-5,12,14,23,27-28H,1-3,6-10,22H2,(H,25,26)/t12-,14?,18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10603330 (2020)
					More data for this Ligand-Target Pair