BDBM290490 1-{[4-(4-cyanonaphthalen-1-yl)isoquinolin-6-yl]thio}cyclobutane-1-carboxylic Acid ::US10100016, Compound 24

SMILES: OC(=O)C1(CCC1)Sc1ccc2cncc(-c3ccc(C#N)c4ccccc34)c2c1

InChI Key: InChIKey=DHMNUFDTDGYKMP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290490   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM290490 (1-{[4-(4-cyanonaphthalen-1-yl)isoquinolin-6-yl]thi...) Show SMILES OC(=O)C1(CCC1)Sc1ccc2cncc(-c3ccc(C#N)c4ccccc34)c2c1 Show InChI InChI=1S/C25H18N2O2S/c26-13-16-7-9-21(20-5-2-1-4-19(16)20)23-15-27-14-17-6-8-18(12-22(17)23)30-25(24(28)29)10-3-11-25/h1-2,4-9,12,14-15H,3,10-11H2,(H,28,29)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...				US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ
					More data for this Ligand-Target Pair