BDBM290843 2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)phenylamino)pyrimidine-5-carboxamide::US9579320, Example 245

SMILES: N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2ccc3OCCOc3c2)n1

InChI Key: InChIKey=ZUPKFEKGWMSPGM-VQTJNVASSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290843   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM290843 (2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(2,3-dihyd...) Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2ccc3OCCOc3c2)n1 |r| Show InChI InChI=1S/C25H28N6O3/c26-19-6-1-2-7-20(19)30-25-28-14-18(23(27)32)24(31-25)29-17-5-3-4-15(12-17)16-8-9-21-22(13-16)34-11-10-33-21/h3-5,8-9,12-14,19-20H,1-2,6-7,10-11,26H2,(H2,27,32)(H2,28,29,30,31)/t19-,20+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	7.5	25
Portola Pharmaceuticals, Inc. US Patent					Assay Description Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...				US Patent US9579320 (2017) BindingDB Entry DOI: 10.7270/Q2K07692
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