BDBM290997 2-((2R,3R)-2-amino-3-methoxylbutylamino)-4-(1-ethyl-1H-indol-4-ylamino)pyrimidine-5-carboxamide::US9579320, Example 442
SMILES: CCn1ccc2c(Nc3nc(NC[C@@H](N)[C@@H](C)OC)ncc3C(N)=O)cccc12
InChI Key: InChIKey=IZHJFRCOJIOIEK-IUODEOHRSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM290997 (2-((2R,3R)-2-amino-3-methoxylbutylamino)-4-(1-ethy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Portola Pharmaceuticals, Inc. US Patent | Assay Description Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi... | US Patent US9579320 (2017) BindingDB Entry DOI: 10.7270/Q2K07692 | |||||||||||
More data for this Ligand-Target Pair |