BDBM291185 N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(6-methoxypyridin-3-yl)-1,5-naphthyridine-2-carboxamide::US9580418, Example 7::US9890162, Example 7

SMILES: COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1

InChI Key: InChIKey=JIYXIPLMAZJNTL-AKQVGLANSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291185   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM291185 (N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...) Show SMILES COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1 |r| Show InChI InChI=1S/C26H27N7O3/c1-15-13-33(14-18(27)25(15)34)23-7-8-28-12-22(23)32-26(35)20-5-4-19-21(31-20)9-17(11-29-19)16-3-6-24(36-2)30-10-16/h3-12,15,18,25,34H,13-14,27H2,1-2H3,(H,32,35)/t15-,18+,25+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				US Patent US9580418 (2017) BindingDB Entry DOI: 10.7270/Q2X92DB9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM291185 (N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...) Show SMILES COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1 |r| Show InChI InChI=1S/C26H27N7O3/c1-15-13-33(14-18(27)25(15)34)23-7-8-28-12-22(23)32-26(35)20-5-4-19-21(31-20)9-17(11-29-19)16-3-6-24(36-2)30-10-16/h3-12,15,18,25,34H,13-14,27H2,1-2H3,(H,32,35)/t15-,18+,25+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				US Patent US9580418 (2017) BindingDB Entry DOI: 10.7270/Q2X92DB9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM291185 (N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...) Show SMILES COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1 |r| Show InChI InChI=1S/C26H27N7O3/c1-15-13-33(14-18(27)25(15)34)23-7-8-28-12-22(23)32-26(35)20-5-4-19-21(31-20)9-17(11-29-19)16-3-6-24(36-2)30-10-16/h3-12,15,18,25,34H,13-14,27H2,1-2H3,(H,32,35)/t15-,18+,25+/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bryn Mawr College					Assay Description Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...				J Med Chem 51: 4968-77 (2008) BindingDB Entry DOI: 10.7270/Q2ZC856W
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM291185 (N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...) Show SMILES COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1 |r| Show InChI InChI=1S/C26H27N7O3/c1-15-13-33(14-18(27)25(15)34)23-7-8-28-12-22(23)32-26(35)20-5-4-19-21(31-20)9-17(11-29-19)16-3-6-24(36-2)30-10-16/h3-12,15,18,25,34H,13-14,27H2,1-2H3,(H,32,35)/t15-,18+,25+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bryn Mawr College					Assay Description Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...				J Med Chem 51: 4968-77 (2008) BindingDB Entry DOI: 10.7270/Q2ZC856W
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM291185 (N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...) Show SMILES COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1 |r| Show InChI InChI=1S/C26H27N7O3/c1-15-13-33(14-18(27)25(15)34)23-7-8-28-12-22(23)32-26(35)20-5-4-19-21(31-20)9-17(11-29-19)16-3-6-24(36-2)30-10-16/h3-12,15,18,25,34H,13-14,27H2,1-2H3,(H,32,35)/t15-,18+,25+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Bryn Mawr College					Assay Description Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...				J Med Chem 51: 4968-77 (2008) BindingDB Entry DOI: 10.7270/Q2ZC856W
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM291185 (N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...) Show SMILES COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1 |r| Show InChI InChI=1S/C26H27N7O3/c1-15-13-33(14-18(27)25(15)34)23-7-8-28-12-22(23)32-26(35)20-5-4-19-21(31-20)9-17(11-29-19)16-3-6-24(36-2)30-10-16/h3-12,15,18,25,34H,13-14,27H2,1-2H3,(H,32,35)/t15-,18+,25+/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				US Patent US9580418 (2017) BindingDB Entry DOI: 10.7270/Q2X92DB9
					More data for this Ligand-Target Pair