BDBM292051 7-Chloro-5-(2-isopropyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]pyridin-3-yl)indolin-::US10100045, Example 22

SMILES: CC(C)n1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C(F)(F)F

InChI Key: InChIKey=VRTYPMFJKBAJTP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 292051   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292051 (7-Chloro-5-(2-isopropyl-5-(trifluoromethyl)-2H-pyr...) Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C(F)(F)F Show InChI InChI=1S/C18H14ClF3N4O/c1-8(2)26-17(10-5-9-7-14(27)24-15(9)11(19)6-10)16-12(25-26)3-4-13(23-16)18(20,21)22/h3-6,8H,7H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.251	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair