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SMILES: Cc1cc(cc2n(C)c(Cc3c(Cl)ccc(C(=O)N4CC(CC(O)=O)C4)c3Cl)cc12)C(F)(F)F

InChI Key: InChIKey=QXJBVMZDEVSQLX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 292732   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM292732
PNG
(US10106501, Example B-9)
Show SMILES Cc1cc(cc2n(C)c(Cc3c(Cl)ccc(C(=O)N4CC(CC(O)=O)C4)c3Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C24H21Cl2F3N2O3/c1-12-5-14(24(27,28)29)7-20-17(12)8-15(30(20)2)9-18-19(25)4-3-16(22(18)26)23(34)31-10-13(11-31)6-21(32)33/h3-5,7-8,13H,6,9-11H2,1-2H3,(H,32,33)
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...

US Patent US10106501 (2018)


BindingDB Entry DOI: 10.7270/Q2G44SBV
More data for this
Ligand-Target Pair