BDBM292984 US10105367, Example 270::US10376514, Example 270

SMILES: COc1ccc(Cn2c3ncc(cc3c3ncnn3c2=O)C(F)CN2C[C@H](C)O[C@H](C)C2)cc1

InChI Key: InChIKey=CRJRMKHOQXXRGM-GWTOYCKXSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292984   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM292984 (US10105367, Example 270 | US10376514, Example 270) Show SMILES COc1ccc(Cn2c3ncc(cc3c3ncnn3c2=O)C(F)CN2C[C@H](C)O[C@H](C)C2)cc1 |r| Show InChI InChI=1S/C24H27FN6O3/c1-15-10-29(11-16(2)34-15)13-21(25)18-8-20-22(26-9-18)30(24(32)31-23(20)27-14-28-31)12-17-4-6-19(33-3)7-5-17/h4-9,14-16,21H,10-13H2,1-3H3/t15-,16+,21?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...				US Patent US10376514 (2019) BindingDB Entry DOI: 10.7270/Q2ST7S6W
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM292984 (US10105367, Example 270 | US10376514, Example 270) Show SMILES COc1ccc(Cn2c3ncc(cc3c3ncnn3c2=O)C(F)CN2C[C@H](C)O[C@H](C)C2)cc1 |r| Show InChI InChI=1S/C24H27FN6O3/c1-15-10-29(11-16(2)34-15)13-21(25)18-8-20-22(26-9-18)30(24(32)31-23(20)27-14-28-31)12-17-4-6-19(33-3)7-5-17/h4-9,14-16,21H,10-13H2,1-3H3/t15-,16+,21?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
DART NEUROSCIENCE (CAYMAN) LTD. US Patent					Assay Description PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...				US Patent US10105367 (2018) BindingDB Entry DOI: 10.7270/Q2KW5J3Q
					More data for this Ligand-Target Pair