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BDBM293315 US10106504, Example 52

SMILES: Cc1cc(ncn1)N1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1

InChI Key: InChIKey=WGSYUINWBNJWPK-UMSFTDKQSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 293315   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)		BDBM293315
PNG
(US10106504, Example 52)
Show SMILES Cc1cc(ncn1)N1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1 |r|
Show InChI InChI=1S/C36H39FN4O4/c1-20-14-29(39-19-38-20)41-12-11-23-15-24(9-10-26(23)18-41)30-21(2)40-22(3)31(34(35(42)43)45-36(4,5)6)32(30)27-16-25-8-7-13-44-33(25)28(37)17-27/h9-10,14-17,19,34H,7-8,11-13,18H2,1-6H3,(H,42,43)/t34-/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...

US Patent US10106504 (2018)


BindingDB Entry DOI: 10.7270/Q2BC41K2
More data for this
Ligand-Target Pair