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BDBM293330 US10106504, Example 67

SMILES: Cc1cc(ncn1)N1CCc2cc(ccc2C1)-c1c(CCCC2CCOCC2)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1

InChI Key: InChIKey=AOVRJRIEUMNCLZ-RWYGWLOXSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 293330   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)		BDBM293330
PNG
(US10106504, Example 67)
Show SMILES Cc1cc(ncn1)N1CCc2cc(ccc2C1)-c1c(CCCC2CCOCC2)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1 |r|
Show InChI InChI=1S/C43H52N4O5/c1-27-22-37(45-26-44-27)47-18-15-30-23-32(11-12-34(30)25-47)39-35(10-6-8-29-16-20-50-21-17-29)46-28(2)38(41(42(48)49)52-43(3,4)5)40(39)33-13-14-36-31(24-33)9-7-19-51-36/h11-14,22-24,26,29,41H,6-10,15-21,25H2,1-5H3,(H,48,49)/t41-/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...

US Patent US10106504 (2018)


BindingDB Entry DOI: 10.7270/Q2BC41K2
More data for this
Ligand-Target Pair