BDBM293660 3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-::US10106534, Example 2
SMILES: CN(c1ccccc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
InChI Key: InChIKey=XSMABFRQESMONQ-SFHVURJKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | 25 |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10106534 (2018) BindingDB Entry DOI: 10.7270/Q2JW8GZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
jmjd3 (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Celgene Quanticel Research, Inc. US Patent | Assay Description The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com... | US Patent US10106534 (2018) BindingDB Entry DOI: 10.7270/Q2JW8GZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of KDM4C (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of KDM4C (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 3A (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of KDM3A (unknown origin) using biotinylated H3K9me1 peptide and alpha-ketoglutarate as substrate measured after 20 mins by LANCE TR-FRET ... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 3B (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of KDM3B (unknown origin) using biotinylated H3K9me1 peptide and alpha-ketoglutarate as substrate measured after 20 mins by LANCE TR-FRET ... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4A (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of KDM4A (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of KDM5B (unknown origin) using biotinylated H3K4me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 7A/7B (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of PHF8 (unknown origin) using biotinylated H3K9me1 peptide and alpha-ketoglutarate as substrate measured after 20 mins by LANCE TR-FRET a... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of full-length KDM4C (unknown origin) expressed in human KYSE-150 cells assessed as increase in H3K36me3 level after 24 hrs by Western blo... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 6B (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of KDM6B (unknown origin) using biotinylated H3K27me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substra... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4B (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of KDM4B (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Lysine-specific demethylase 2B (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of KDM2B (unknown origin) using biotinylated H3K36me2 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substra... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4D (Homo sapiens (Human)) | BDBM293660 (3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of KDM4D (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair |