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Enter Data

BDBM293969 (2S)-5-(2-(4-((3-(2- Methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3-yn- 1-yl)-1H-tetrazole::US10106553, Compound 1

SMILES: CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1

InChI Key:

Data: 3 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 293969
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM293969 ((2S)-5-(2-(4-((3-(2- Methylphenyl)benzo[b]thiophen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	25
Janssen Pharmaceutica NV US Patent					Assay Description Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...				US Patent US10106553 (2018) BindingDB Entry DOI: 10.7270/Q21Z46FD
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM293969 ((2S)-5-(2-(4-((3-(2- Methylphenyl)benzo[b]thiophen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay				Citation and Details Article DOI: 10.1016/j.bmcl.2017.12.022 BindingDB Entry DOI: 10.7270/Q2833VN4
TBA					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Rattus norvegicus)	BDBM293969 ((2S)-5-(2-(4-((3-(2- Methylphenyl)benzo[b]thiophen...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assay				Citation and Details Article DOI: 10.1016/j.bmcl.2017.12.022 BindingDB Entry DOI: 10.7270/Q2833VN4
TBA					More data for this Ligand-Target Pair