BDBM294093 1-Benzyl-7-chloro-N′dodecanoyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide::US9585879, 62::US9757369, 62
SMILES: CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2ccc(Cl)cc2n(Cc2ccccc2)c1=O
InChI Key: InChIKey=VYWSBPSJPPGGCG-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM294093 (1-Benzyl-7-chloro-N′dodecanoyl-4-hydroxy-2-o...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.99E+3 | n/a | n/a | n/a | n/a | n/a | 30 |
Consejo Superior de Investigaciones Cientificas (CSIC) US Patent | Assay Description The enzyme inhibition assays were performed using the luminometric methodology of kinase-Glo. The recombinant human GSK3 enzyme (catalogue no. 14-306... | US Patent US9585879 (2017) BindingDB Entry DOI: 10.7270/Q2HX1FQR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM294093 (1-Benzyl-7-chloro-N′dodecanoyl-4-hydroxy-2-o...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigaciones Biol�gicas-CSIC , Ramiro de Maeztu 9, 28040 Madrid, Spain. Curated by ChEMBL | Assay Description Allosteric inhibition of human recombinant full length N-terminal GST-tagged GSK3beta expressed in fall armyworm Sf9 cells after 30 min in presence o... | J Med Chem 60: 4983-5001 (2017) Article DOI: 10.1021/acs.jmedchem.7b00395 BindingDB Entry DOI: 10.7270/Q2NC63B9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM294093 (1-Benzyl-7-chloro-N′dodecanoyl-4-hydroxy-2-o...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Consejo Superior de Investigaciones Cientificas (CSIC) US Patent | Assay Description The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30... | US Patent US9757369 (2017) BindingDB Entry DOI: 10.7270/Q2NK3H5Z | |||||||||||
More data for this Ligand-Target Pair |