BDBM294499 1-{2-[(E)-2-{4,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl}ethenyl]-1-phenyl-1H-imidazol-4-yl}pyrrolidin-2-one::US9586970, 20

SMILES: Cc1cnc(C)n2nc(\C=C\c3nc(cn3-c3ccccc3)N3CCCC3=O)nc12

InChI Key: InChIKey=OCICYHNNUDBBEY-ZHACJKMWSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 294499   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM294499 (1-{2-[(E)-2-{4,7-Dimethyl-[1,2,4]triazolo[1,5-a]py...) Show SMILES Cc1cnc(C)n2nc(\C=C\c3nc(cn3-c3ccccc3)N3CCCC3=O)nc12 Show InChI InChI=1S/C22H21N7O/c1-15-13-23-16(2)29-22(15)24-18(26-29)10-11-19-25-20(27-12-6-9-21(27)30)14-28(19)17-7-4-3-5-8-17/h3-5,7-8,10-11,13-14H,6,9,12H2,1-2H3/b11-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19.4	n/a	n/a	n/a	n/a	n/a	25
Hoffmann-La Roche Inc. US Patent					Assay Description The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM...				US Patent US9586970 (2017) BindingDB Entry DOI: 10.7270/Q200045H
					More data for this Ligand-Target Pair