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SMILES: Cc1c(nc2ccc(CCc3nc(cn3-c3ccccc3)N3CCCC3=O)nn12)C(F)(F)F

InChI Key: InChIKey=NCBRUJGANGAGIJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 294502   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM294502
PNG
(1-(2-{2-[3-Methyl-2-(trifluoromethyl)imidazo[1,2-b...)
Show SMILES Cc1c(nc2ccc(CCc3nc(cn3-c3ccccc3)N3CCCC3=O)nn12)C(F)(F)F
Show InChI InChI=1S/C23H21F3N6O/c1-15-22(23(24,25)26)28-19-12-10-16(29-32(15)19)9-11-18-27-20(30-13-5-8-21(30)33)14-31(18)17-6-3-2-4-7-17/h2-4,6-7,10,12,14H,5,8-9,11,13H2,1H3
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 3.10n/an/an/an/an/a25



Hoffmann-La Roche Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM...

US Patent US9586970 (2017)


BindingDB Entry DOI: 10.7270/Q200045H
More data for this
Ligand-Target Pair