BDBM294640 US10112899, Example 119

SMILES: Cc1ccc(cc1)-c1c(C)c2CN(Cc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)C(=O)c1cc(F)cc(F)c1

InChI Key: InChIKey=LCDIXFIMBXCKLG-MHZLTWQESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 294640   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM294640 (US10112899, Example 119) Show SMILES Cc1ccc(cc1)-c1c(C)c2CN(Cc2c(C)c1[C@H](OC(C)(C)C)C(O)=O)C(=O)c1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C30H31F2NO4/c1-16-7-9-19(10-8-16)25-17(2)23-14-33(28(34)20-11-21(31)13-22(32)12-20)15-24(23)18(3)26(25)27(29(35)36)37-30(4,5)6/h7-13,27H,14-15H2,1-6H3,(H,35,36)/t27-/m0/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
ViiV HEALTHCARE UK LIMITED US Patent					Assay Description Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...				US Patent US10112899 (2018) BindingDB Entry DOI: 10.7270/Q2KP8465
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