null

SMILES: CC(C)c1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O

InChI Key: InChIKey=VOZATGBILRZYMT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 295110   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM295110 (3-(6-Amino-5-(3-isopropylisoxazol-5-yl)pyridin-3-y...) Show SMILES CC(C)c1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O Show InChI InChI=1S/C22H28N4O4S/c1-13(2)19-10-20(30-26-19)18-8-15(11-24-21(18)23)17-9-16(7-6-14(17)3)31(28,29)25-12-22(4,5)27/h6-11,13,25,27H,12H2,1-5H3,(H2,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM295110 (3-(6-Amino-5-(3-isopropylisoxazol-5-yl)pyridin-3-y...) Show SMILES CC(C)c1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O Show InChI InChI=1S/C22H28N4O4S/c1-13(2)19-10-20(30-26-19)18-8-15(11-24-21(18)23)17-9-16(7-6-14(17)3)31(28,29)25-12-22(4,5)27/h6-11,13,25,27H,12H2,1-5H3,(H2,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3 (Homo sapiens (Human))	BDBM295110 (3-(6-Amino-5-(3-isopropylisoxazol-5-yl)pyridin-3-y...) Show SMILES CC(C)c1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O Show InChI InChI=1S/C22H28N4O4S/c1-13(2)19-10-20(30-26-19)18-8-15(11-24-21(18)23)17-9-16(7-6-14(17)3)31(28,29)25-12-22(4,5)27/h6-11,13,25,27H,12H2,1-5H3,(H2,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM295110 (3-(6-Amino-5-(3-isopropylisoxazol-5-yl)pyridin-3-y...) Show SMILES CC(C)c1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O Show InChI InChI=1S/C22H28N4O4S/c1-13(2)19-10-20(30-26-19)18-8-15(11-24-21(18)23)17-9-16(7-6-14(17)3)31(28,29)25-12-22(4,5)27/h6-11,13,25,27H,12H2,1-5H3,(H2,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG US Patent					Assay Description Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of interest. ...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM295110 (3-(6-Amino-5-(3-isopropylisoxazol-5-yl)pyridin-3-y...) Show SMILES CC(C)c1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O Show InChI InChI=1S/C22H28N4O4S/c1-13(2)19-10-20(30-26-19)18-8-15(11-24-21(18)23)17-9-16(7-6-14(17)3)31(28,29)25-12-22(4,5)27/h6-11,13,25,27H,12H2,1-5H3,(H2,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG US Patent					Assay Description The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM295110 (3-(6-Amino-5-(3-isopropylisoxazol-5-yl)pyridin-3-y...) Show SMILES CC(C)c1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O Show InChI InChI=1S/C22H28N4O4S/c1-13(2)19-10-20(30-26-19)18-8-15(11-24-21(18)23)17-9-16(7-6-14(17)3)31(28,29)25-12-22(4,5)27/h6-11,13,25,27H,12H2,1-5H3,(H2,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	540	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG US Patent					Assay Description The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (Homo sapiens (Human))	BDBM295110 (3-(6-Amino-5-(3-isopropylisoxazol-5-yl)pyridin-3-y...) Show SMILES CC(C)c1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O Show InChI InChI=1S/C22H28N4O4S/c1-13(2)19-10-20(30-26-19)18-8-15(11-24-21(18)23)17-9-16(7-6-14(17)3)31(28,29)25-12-22(4,5)27/h6-11,13,25,27H,12H2,1-5H3,(H2,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...				US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9
					More data for this Ligand-Target Pair