BDBM296143 2-[4-[4-(1-methoxy-2-methylpropan-2-yl)- N-methylanilino]phenoxy]pyrido[3,4- d]pyrimidin-4-ol::US10112940, Example 67::US10202381, Example 67::US10208039, Example 67::US10611763, Example 67::US10815234, Example 67

SMILES: COCC(C)(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1

InChI Key: InChIKey=LTSJEPZXATVUOB-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 296143   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM296143 (2-[4-[4-(1-methoxy-2-methylpropan-2-yl)- N-methyla...) Show SMILES COCC(C)(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1 Show InChI InChI=1S/C25H26N4O3/c1-25(2,16-31-4)17-5-7-18(8-6-17)29(3)19-9-11-20(12-10-19)32-24-27-22-15-26-14-13-21(22)23(30)28-24/h5-15H,16H2,1-4H3,(H,27,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10112940 (2018) BindingDB Entry DOI: 10.7270/Q2X0692W
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM296143 (2-[4-[4-(1-methoxy-2-methylpropan-2-yl)- N-methyla...) Show SMILES COCC(C)(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1 Show InChI InChI=1S/C25H26N4O3/c1-25(2,16-31-4)17-5-7-18(8-6-17)29(3)19-9-11-20(12-10-19)32-24-27-22-15-26-14-13-21(22)23(30)28-24/h5-15H,16H2,1-4H3,(H,27,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...				US Patent US10202381 (2019) BindingDB Entry DOI: 10.7270/Q2SX6GBM
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)(2-372) (Homo sapiens (Human))	BDBM296143 (2-[4-[4-(1-methoxy-2-methylpropan-2-yl)- N-methyla...) Show SMILES COCC(C)(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1 Show InChI InChI=1S/C25H26N4O3/c1-25(2,16-31-4)17-5-7-18(8-6-17)29(3)19-9-11-20(12-10-19)32-24-27-22-15-26-14-13-21(22)23(30)28-24/h5-15H,16H2,1-4H3,(H,27,28,30)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10815234 (2020)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM296143 (2-[4-[4-(1-methoxy-2-methylpropan-2-yl)- N-methyla...) Show SMILES COCC(C)(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1 Show InChI InChI=1S/C25H26N4O3/c1-25(2,16-31-4)17-5-7-18(8-6-17)29(3)19-9-11-20(12-10-19)32-24-27-22-15-26-14-13-21(22)23(30)28-24/h5-15H,16H2,1-4H3,(H,27,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10611763 (2020)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM296143 (2-[4-[4-(1-methoxy-2-methylpropan-2-yl)- N-methyla...) Show SMILES COCC(C)(C)c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1 Show InChI InChI=1S/C25H26N4O3/c1-25(2,16-31-4)17-5-7-18(8-6-17)29(3)19-9-11-20(12-10-19)32-24-27-22-15-26-14-13-21(22)23(30)28-24/h5-15H,16H2,1-4H3,(H,27,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...				US Patent US10208039 (2019) BindingDB Entry DOI: 10.7270/Q241706J
					More data for this Ligand-Target Pair