BDBM296185 2-[4-[N-methyl-4-(1,1,1-trifluoropropan-2- yl)anilino]phenoxy]pyrido[3,4-d]pyrimidin- 4-ol::US10112940, Example 108::US10202381, Example 108::US10208039, Example 108::US10611763, Example 108::US10815234, Example 108

SMILES: CC(c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1)C(F)(F)F

InChI Key: InChIKey=WQGWRPIKYVWCHC-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 296185   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM296185 (2-[4-[N-methyl-4-(1,1,1-trifluoropropan-2- yl)anil...) Show SMILES CC(c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1)C(F)(F)F Show InChI InChI=1S/C23H19F3N4O2/c1-14(23(24,25)26)15-3-5-16(6-4-15)30(2)17-7-9-18(10-8-17)32-22-28-20-13-27-12-11-19(20)21(31)29-22/h3-14H,1-2H3,(H,28,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10112940 (2018) BindingDB Entry DOI: 10.7270/Q2X0692W
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM296185 (2-[4-[N-methyl-4-(1,1,1-trifluoropropan-2- yl)anil...) Show SMILES CC(c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1)C(F)(F)F Show InChI InChI=1S/C23H19F3N4O2/c1-14(23(24,25)26)15-3-5-16(6-4-15)30(2)17-7-9-18(10-8-17)32-22-28-20-13-27-12-11-19(20)21(31)29-22/h3-14H,1-2H3,(H,28,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...				US Patent US10202381 (2019) BindingDB Entry DOI: 10.7270/Q2SX6GBM
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C [2-372] (Homo sapiens (Human))	BDBM296185 (2-[4-[N-methyl-4-(1,1,1-trifluoropropan-2- yl)anil...) Show SMILES CC(c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1)C(F)(F)F Show InChI InChI=1S/C23H19F3N4O2/c1-14(23(24,25)26)15-3-5-16(6-4-15)30(2)17-7-9-18(10-8-17)32-22-28-20-13-27-12-11-19(20)21(31)29-22/h3-14H,1-2H3,(H,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10815234 (2020)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM296185 (2-[4-[N-methyl-4-(1,1,1-trifluoropropan-2- yl)anil...) Show SMILES CC(c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1)C(F)(F)F Show InChI InChI=1S/C23H19F3N4O2/c1-14(23(24,25)26)15-3-5-16(6-4-15)30(2)17-7-9-18(10-8-17)32-22-28-20-13-27-12-11-19(20)21(31)29-22/h3-14H,1-2H3,(H,28,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10611763 (2020)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM296185 (2-[4-[N-methyl-4-(1,1,1-trifluoropropan-2- yl)anil...) Show SMILES CC(c1ccc(cc1)N(C)c1ccc(Oc2nc(O)c3ccncc3n2)cc1)C(F)(F)F Show InChI InChI=1S/C23H19F3N4O2/c1-14(23(24,25)26)15-3-5-16(6-4-15)30(2)17-7-9-18(10-8-17)32-22-28-20-13-27-12-11-19(20)21(31)29-22/h3-14H,1-2H3,(H,28,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...				US Patent US10208039 (2019) BindingDB Entry DOI: 10.7270/Q241706J
					More data for this Ligand-Target Pair