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BDBM29707 Pyridoimidazolone, 5g

SMILES: FC(F)(F)c1ccc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)cc2)cc1

InChI Key: InChIKey=YHNBWLYKHUTSNA-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 29707   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
B-RAF V600E


(Homo sapiens (Human))		BDBM29707
PNG
(Pyridoimidazolone, 5g)
Show SMILES FC(F)(F)c1ccc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)cc2)cc1
Show InChI InChI=1S/C20H14F3N5O3/c21-20(22,23)11-1-3-12(4-2-11)25-18(29)26-13-5-7-14(8-6-13)31-15-9-10-24-17-16(15)27-19(30)28-17/h1-10H,(H2,25,26,29)(H2,24,27,28,30)
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Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.222



The Institute of Cancer Research



Assay Description
The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...

J Med Chem 52: 2255-64 (2009)


Article DOI: 10.1021/jm801509w
BindingDB Entry DOI: 10.7270/Q2PK0DGX
More data for this
Ligand-Target Pair