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SMILES: FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)cc1

InChI Key: InChIKey=MNTQCNXYWXTJOC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 29740   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf [V600E]


(Homo sapiens (Human))		BDBM29740
PNG
(Pyridoimidazolone, 29d)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)cc1
Show InChI InChI=1S/C19H13F3N4O4S/c20-19(21,22)11-1-7-14(8-2-11)31(28,29)26-12-3-5-13(6-4-12)30-15-9-10-23-17-16(15)24-18(27)25-17/h1-10,26H,(H2,23,24,25,27)
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Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



The Institute of Cancer Research



Assay Description
The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...

J Med Chem 52: 2255-64 (2009)


Article DOI: 10.1021/jm801509w
BindingDB Entry DOI: 10.7270/Q2PK0DGX
More data for this
Ligand-Target Pair