BDBM29817 4-indolylamino-5-phenyl-3-pyridinecarbonitrile, 7a

SMILES: COCCOc1cc(ccc1OC)-c1cncc(C#N)c1Nc1cccc2[nH]ccc12

InChI Key: InChIKey=OQGXWJUPOQZCMP-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 29817   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C theta type (Homo sapiens (Human))	BDBM29817 (4-indolylamino-5-phenyl-3-pyridinecarbonitrile, 7a) Show SMILES COCCOc1cc(ccc1OC)-c1cncc(C#N)c1Nc1cccc2[nH]ccc12 Show InChI InChI=1S/C24H22N4O3/c1-29-10-11-31-23-12-16(6-7-22(23)30-2)19-15-26-14-17(13-25)24(19)28-21-5-3-4-20-18(21)8-9-27-20/h3-9,12,14-15,27H,10-11H2,1-2H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	7.2	22
Wyeth Research					Assay Description All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...				Bioorg Med Chem Lett 19: 2461-3 (2009) Article DOI: 10.1016/j.bmcl.2009.03.053 BindingDB Entry DOI: 10.7270/Q21R6NVV
					More data for this Ligand-Target Pair