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BDBM29924 substituted 6-aminoquinoline-3-carbonitrile, 35

SMILES: CCCN1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1

InChI Key: InChIKey=DATRTCJGCFQUHH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 29924   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))		BDBM29924
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 35)
Show SMILES CCCN1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Show InChI InChI=1S/C27H27Cl2FN8/c1-2-7-37-8-5-21(6-9-37)38-16-20(35-36-38)15-32-19-10-22-26(34-18-3-4-25(30)23(28)11-18)17(13-31)14-33-27(22)24(29)12-19/h3-4,10-12,14,16,21,32H,2,5-9,15H2,1H3,(H,33,34)
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PubMed
n/an/a 8.20n/an/an/an/an/an/a



Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...

Bioorg Med Chem Lett 19: 3485-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.009
BindingDB Entry DOI: 10.7270/Q2HT2MN8
More data for this
Ligand-Target Pair