BDBM299339 N-[3-(4-aminoquinazolin-6-yl)-5-fluoro-phenyl]-2-morpholino-acetamide::US9592235, Example 47::US9855269, Compound 39
SMILES: Nc1ncnc2ccc(cc12)-c1cc(F)cc(NC(=O)CN2CCOCC2)c1
InChI Key: InChIKey=WJUQEVXYYUIFRT-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human)) | BDBM299339 (N-[3-(4-aminoquinazolin-6-yl)-5-fluoro-phenyl]-2-m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 273 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research | Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ... | J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human)) | BDBM299339 (N-[3-(4-aminoquinazolin-6-yl)-5-fluoro-phenyl]-2-m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 273 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc. US Patent | Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ... | US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX | |||||||||||
More data for this Ligand-Target Pair |