BDBM299339 N-[3-(4-aminoquinazolin-6-yl)-5-fluoro-phenyl]-2-morpholino-acetamide::US9592235, Example 47::US9855269, Compound 39

SMILES: Nc1ncnc2ccc(cc12)-c1cc(F)cc(NC(=O)CN2CCOCC2)c1

InChI Key: InChIKey=WJUQEVXYYUIFRT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299339   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299339 (N-[3-(4-aminoquinazolin-6-yl)-5-fluoro-phenyl]-2-m...) Show SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(NC(=O)CN2CCOCC2)c1 Show InChI InChI=1S/C20H20FN5O2/c21-15-7-14(13-1-2-18-17(9-13)20(22)24-12-23-18)8-16(10-15)25-19(27)11-26-3-5-28-6-4-26/h1-2,7-10,12H,3-6,11H2,(H,25,27)(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	273	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299339 (N-[3-(4-aminoquinazolin-6-yl)-5-fluoro-phenyl]-2-m...) Show SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(NC(=O)CN2CCOCC2)c1 Show InChI InChI=1S/C20H20FN5O2/c21-15-7-14(13-1-2-18-17(9-13)20(22)24-12-23-18)8-16(10-15)25-19(27)11-26-3-5-28-6-4-26/h1-2,7-10,12H,3-6,11H2,(H,25,27)(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	273	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX
					More data for this Ligand-Target Pair