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SMILES: Nc1ncnc2ccc(cc12)-c1cc(F)cc(NC(=O)CC2CCCO2)c1

InChI Key: InChIKey=QIKFBSMJSRDVSS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299395   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299395 (N-[3-(4-amino- quinazolin-6- yl)-5-fluoro- phenyl]...) Show SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(NC(=O)CC2CCCO2)c1 Show InChI InChI=1S/C20H19FN4O2/c21-14-6-13(12-3-4-18-17(8-12)20(22)24-11-23-18)7-15(9-14)25-19(26)10-16-2-1-5-27-16/h3-4,6-9,11,16H,1-2,5,10H2,(H,25,26)(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	844	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299395 (N-[3-(4-amino- quinazolin-6- yl)-5-fluoro- phenyl]...) Show SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(NC(=O)CC2CCCO2)c1 Show InChI InChI=1S/C20H19FN4O2/c21-14-6-13(12-3-4-18-17(8-12)20(22)24-11-23-18)7-15(9-14)25-19(26)10-16-2-1-5-27-16/h3-4,6-9,11,16H,1-2,5,10H2,(H,25,26)(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	844	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX
					More data for this Ligand-Target Pair