BDBM299411 6-(4-pyridyl) quinazolin- 4-amine::US9592235, Example 204::US9855269, Compound 51

SMILES: Nc1ncnc2ccc(cc12)-c1ccncc1

InChI Key: InChIKey=XUJCXPTZBHANNJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299411   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299411 (6-(4-pyridyl) quinazolin- 4-amine | US9592235, Exa...) Show SMILES Nc1ncnc2ccc(cc12)-c1ccncc1 Show InChI InChI=1S/C13H10N4/c14-13-11-7-10(9-3-5-15-6-4-9)1-2-12(11)16-8-17-13/h1-8H,(H2,14,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299411 (6-(4-pyridyl) quinazolin- 4-amine | US9592235, Exa...) Show SMILES Nc1ncnc2ccc(cc12)-c1ccncc1 Show InChI InChI=1S/C13H10N4/c14-13-11-7-10(9-3-5-15-6-4-9)1-2-12(11)16-8-17-13/h1-8H,(H2,14,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX
					More data for this Ligand-Target Pair