BDBM299423 N-[3-(4-amino- quinazolin-6-yl) phenyl]-2- pyrrolidin-1-yl- acetamide::US9592235, Example 216::US9855269, Compound 63

SMILES: Nc1ncnc2ccc(cc12)-c1cccc(NC(=O)CN2CCCC2)c1

InChI Key: InChIKey=RQVUVEKKIZVJGT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299423   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299423 (N-[3-(4-amino- quinazolin-6-yl) phenyl]-2- pyrroli...) Show SMILES Nc1ncnc2ccc(cc12)-c1cccc(NC(=O)CN2CCCC2)c1 Show InChI InChI=1S/C20H21N5O/c21-20-17-11-15(6-7-18(17)22-13-23-20)14-4-3-5-16(10-14)24-19(26)12-25-8-1-2-9-25/h3-7,10-11,13H,1-2,8-9,12H2,(H,24,26)(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	216	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299423 (N-[3-(4-amino- quinazolin-6-yl) phenyl]-2- pyrroli...) Show SMILES Nc1ncnc2ccc(cc12)-c1cccc(NC(=O)CN2CCCC2)c1 Show InChI InChI=1S/C20H21N5O/c21-20-17-11-15(6-7-18(17)22-13-23-20)14-4-3-5-16(10-14)24-19(26)12-25-8-1-2-9-25/h3-7,10-11,13H,1-2,8-9,12H2,(H,24,26)(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	216	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX
					More data for this Ligand-Target Pair