BDBM299630 (2S,4S)-5-(5′-Chloro-2′-fluorobiphenyl-4-yl)-2-[(2-fluoroethylamino)methyl]-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic Acid::US9593110, Example 81::US9593110, Example 82a::US9593110, Example 83b::US9593110, Example 84b::US9593110, Example 85a

SMILES: CCOC(=O)[C@H](COS(=O)(=O)c1ccc(C)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O

InChI Key: InChIKey=MQNUYORJAHRKHD-LADGPHEKSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 299630   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Homo sapiens (Human))	BDBM299630 ((2S,4S)-5-(5′-Chloro-2′-fluorobiphenyl...) Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(C)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O |r| Show InChI InChI=1S/C28H32BClFNO6S/c1-4-37-28(33)22(18-38-39(35,36)25-12-5-19(2)6-13-25)16-24(32-29(3)34)15-20-7-9-21(10-8-20)26-17-23(30)11-14-27(26)31/h5-14,17,22,24,32,34H,4,15-16,18H2,1-3H3/t22-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravence Biopharma R&D IP, LLC US Patent					Assay Description Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...				US Patent US9593110 (2017) BindingDB Entry DOI: 10.7270/Q2MC9224
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM299630 ((2S,4S)-5-(5′-Chloro-2′-fluorobiphenyl...) Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(C)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O |r| Show InChI InChI=1S/C28H32BClFNO6S/c1-4-37-28(33)22(18-38-39(35,36)25-12-5-19(2)6-13-25)16-24(32-29(3)34)15-20-7-9-21(10-8-20)26-17-23(30)11-14-27(26)31/h5-14,17,22,24,32,34H,4,15-16,18H2,1-3H3/t22-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravence Biopharma R&D IP, LLC US Patent					Assay Description Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...				US Patent US9593110 (2017) BindingDB Entry DOI: 10.7270/Q2MC9224
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM299630 ((2S,4S)-5-(5′-Chloro-2′-fluorobiphenyl...) Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(C)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O |r| Show InChI InChI=1S/C28H32BClFNO6S/c1-4-37-28(33)22(18-38-39(35,36)25-12-5-19(2)6-13-25)16-24(32-29(3)34)15-20-7-9-21(10-8-20)26-17-23(30)11-14-27(26)31/h5-14,17,22,24,32,34H,4,15-16,18H2,1-3H3/t22-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravence Biopharma R&D IP, LLC US Patent					Assay Description Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...				US Patent US9593110 (2017) BindingDB Entry DOI: 10.7270/Q2MC9224
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM299630 ((2S,4S)-5-(5′-Chloro-2′-fluorobiphenyl...) Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(C)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O |r| Show InChI InChI=1S/C28H32BClFNO6S/c1-4-37-28(33)22(18-38-39(35,36)25-12-5-19(2)6-13-25)16-24(32-29(3)34)15-20-7-9-21(10-8-20)26-17-23(30)11-14-27(26)31/h5-14,17,22,24,32,34H,4,15-16,18H2,1-3H3/t22-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravence Biopharma R&D IP, LLC US Patent					Assay Description Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...				US Patent US9593110 (2017) BindingDB Entry DOI: 10.7270/Q2MC9224
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM299630 ((2S,4S)-5-(5′-Chloro-2′-fluorobiphenyl...) Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(C)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O |r| Show InChI InChI=1S/C28H32BClFNO6S/c1-4-37-28(33)22(18-38-39(35,36)25-12-5-19(2)6-13-25)16-24(32-29(3)34)15-20-7-9-21(10-8-20)26-17-23(30)11-14-27(26)31/h5-14,17,22,24,32,34H,4,15-16,18H2,1-3H3/t22-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravence Biopharma R&D IP, LLC US Patent					Assay Description Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...				US Patent US9593110 (2017) BindingDB Entry DOI: 10.7270/Q2MC9224
					More data for this Ligand-Target Pair