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SMILES: COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1n[nH]c(n1)C(F)(F)F)C(O)=O

InChI Key: InChIKey=PMVAVHVYEOVEBT-GOEBONIOSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300249   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300249
PNG
(US9593110, 2-2)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1n[nH]c(n1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C23H21ClF4N4O4/c1-36-11-14(21(34)35)9-16(29-20(33)19-30-22(32-31-19)23(26,27)28)8-12-2-4-13(5-3-12)17-10-15(24)6-7-18(17)25/h2-7,10,14,16H,8-9,11H2,1H3,(H,29,33)(H,34,35)(H,30,31,32)/t14-,16+/m0/s1
PDB

KEGG

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PC cid
PC sid
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair