BDBM3004 3-((3-Chlorophenyl)amino)-4,6-diamino-1H-pyrazolo[3,4-d]pyrimidine::3-N-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4,6-triamine::pyrazolopyrimidine deriv. 2

SMILES: Nc1nc(N)c2c(Nc3cccc(Cl)c3)[nH]nc2n1

InChI Key: InChIKey=YASYSLUSCVNMAJ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 3004   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3004 (3-((3-Chlorophenyl)amino)-4,6-diamino-1H-pyrazolo[...) Show SMILES Nc1nc(N)c2c(Nc3cccc(Cl)c3)[nH]nc2n1 Show InChI InChI=1S/C11H10ClN7/c12-5-2-1-3-6(4-5)15-9-7-8(13)16-11(14)17-10(7)19-18-9/h1-4H,(H6,13,14,15,16,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	7.5	20
Novartis Pharmaceuticals					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 3601-16 (1997) Article DOI: 10.1021/jm970124v BindingDB Entry DOI: 10.7270/Q2H70D0N
					More data for this Ligand-Target Pair
Protein Kinase C, alpha (Bos taurus (bovine))	BDBM3004 (3-((3-Chlorophenyl)amino)-4,6-diamino-1H-pyrazolo[...) Show SMILES Nc1nc(N)c2c(Nc3cccc(Cl)c3)[nH]nc2n1 Show InChI InChI=1S/C11H10ClN7/c12-5-2-1-3-6(4-5)15-9-7-8(13)16-11(14)17-10(7)19-18-9/h1-4H,(H6,13,14,15,16,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	n/a
Novartis Pharmaceuticals					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 3601-16 (1997) Article DOI: 10.1021/jm970124v BindingDB Entry DOI: 10.7270/Q2H70D0N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM3004 (3-((3-Chlorophenyl)amino)-4,6-diamino-1H-pyrazolo[...) Show SMILES Nc1nc(N)c2c(Nc3cccc(Cl)c3)[nH]nc2n1 Show InChI InChI=1S/C11H10ClN7/c12-5-2-1-3-6(4-5)15-9-7-8(13)16-11(14)17-10(7)19-18-9/h1-4H,(H6,13,14,15,16,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	20
Novartis Pharmaceuticals					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 3601-16 (1997) Article DOI: 10.1021/jm970124v BindingDB Entry DOI: 10.7270/Q2H70D0N
					More data for this Ligand-Target Pair
Tyrosine-protein kinase transforming protein Abl (Abelson murine leukemia virus)	BDBM3004 (3-((3-Chlorophenyl)amino)-4,6-diamino-1H-pyrazolo[...) Show SMILES Nc1nc(N)c2c(Nc3cccc(Cl)c3)[nH]nc2n1 Show InChI InChI=1S/C11H10ClN7/c12-5-2-1-3-6(4-5)15-9-7-8(13)16-11(14)17-10(7)19-18-9/h1-4H,(H6,13,14,15,16,17,18,19)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	7.5	20
Novartis Pharmaceuticals					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 3601-16 (1997) Article DOI: 10.1021/jm970124v BindingDB Entry DOI: 10.7270/Q2H70D0N
					More data for this Ligand-Target Pair