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SMILES: CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)C(=O)OC)n1

InChI Key: InChIKey=CXSAXFIKCXYTNV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 302011   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM302011
PNG
(US9598405, 2.10)
Show SMILES CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)C(=O)OC)n1 |(-7.3,.16,;-5.76,.1,;-5.04,-1.26,;-3.5,-1.31,;-2.69,-0,;-2.78,-2.67,;-1.24,-2.72,;-.52,-4.08,;-1.33,-5.39,;-.06,-6.25,;-2.87,-5.34,;-3.6,-3.98,;-1.33,-6.93,;-2.58,-7.84,;-2.1,-9.3,;-.56,-9.3,;-.09,-7.84,;.34,-10.55,;1.87,-10.38,;2.78,-11.63,;4.31,-11.47,;2.15,-13.04,;.62,-13.2,;-.01,-14.61,;.9,-15.85,;.27,-17.26,;1.18,-18.5,;2.71,-18.34,;3.34,-16.94,;2.43,-15.69,;.55,-19.91,;-.98,-20.07,;1.46,-21.16,;2.99,-21,;-.28,-11.95,)|
Show InChI InChI=1S/C25H28N4O5S/c1-4-34-23(31)16-5-8-25(32,9-6-16)24-27-14-19(35-24)18-11-15(2)12-21(28-18)29-20-13-17(7-10-26-20)22(30)33-3/h7,10-14,16,32H,4-6,8-9H2,1-3H3,(H,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.84n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...

US Patent US9598405 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair