null

SMILES: Cc1cc(Nc2cc(OCCCN)ccn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O

InChI Key: InChIKey=FCXQYHYJZIHCGC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 302012   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302012 (US9598405, 2.11) Show SMILES Cc1cc(Nc2cc(OCCCN)ccn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O |(5.83,2.98,;4.5,2.21,;3.17,2.98,;1.83,2.21,;.5,2.98,;.5,4.52,;1.83,5.29,;1.83,6.83,;3.17,7.6,;3.17,9.14,;4.5,9.91,;4.5,11.45,;5.83,12.22,;.5,7.6,;-.84,6.83,;-.84,5.29,;1.83,.67,;3.17,-.1,;4.5,.67,;3.17,-1.64,;4.41,-2.55,;3.94,-4.01,;2.4,-4.01,;1.92,-2.55,;1.49,-5.26,;2.87,-5.93,;1.07,-6.74,;-.43,-7.11,;-1.5,-6,;-1.07,-4.52,;.42,-4.15,;-2.99,-6.38,;-4.06,-5.27,;-3.42,-7.86,)| Show InChI InChI=1S/C24H29N5O4S/c1-15-11-18(19-14-27-23(34-19)24(32)6-3-16(4-7-24)22(30)31)28-21(12-15)29-20-13-17(5-9-26-20)33-10-2-8-25/h5,9,11-14,16,32H,2-4,6-8,10,25H2,1H3,(H,30,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.911	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair