BDBM302470 N5-(2-Fluoro-3- (trifluoromethyl)phenyl)- 2-(3-fluorophenyl)-6,7- dihydropyrazolo[1,5-a] pyrazine-3,5(4H)- dicarboxamide::US9598423, Example 36

SMILES: NC(=O)c1c2CN(CCn2nc1-c1cccc(F)c1)C(=O)Nc1cccc(c1F)C(F)(F)F

InChI Key: InChIKey=NZUKTPLKRWAMRD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 302470   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM302470 (N5-(2-Fluoro-3- (trifluoromethyl)phenyl)- 2-(3-flu...) Show SMILES NC(=O)c1c2CN(CCn2nc1-c1cccc(F)c1)C(=O)Nc1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C21H16F5N5O2/c22-12-4-1-3-11(9-12)18-16(19(27)32)15-10-30(7-8-31(15)29-18)20(33)28-14-6-2-5-13(17(14)23)21(24,25)26/h1-6,9H,7-8,10H2,(H2,27,32)(H,28,33)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9598423 (2017) BindingDB Entry DOI: 10.7270/Q2FJ2JT9
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM302470 (N5-(2-Fluoro-3- (trifluoromethyl)phenyl)- 2-(3-flu...) Show SMILES NC(=O)c1c2CN(CCn2nc1-c1cccc(F)c1)C(=O)Nc1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C21H16F5N5O2/c22-12-4-1-3-11(9-12)18-16(19(27)32)15-10-30(7-8-31(15)29-18)20(33)28-14-6-2-5-13(17(14)23)21(24,25)26/h1-6,9H,7-8,10H2,(H2,27,32)(H,28,33)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9598423 (2017) BindingDB Entry DOI: 10.7270/Q2FJ2JT9
					More data for this Ligand-Target Pair