BDBM303058 (2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1H-indol-1- yl)acetyl)-4-fluoro-N- (1-(2-fluoro-5- methylphenyl)-2- oxopiperidin-3- yl)pyrrolidine-2- carboxamide::US10660876, Cmpd No. 63::US9598446, Compound 63

SMILES: CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NC2CCCN(C2=O)c2cc(C)ccc2F)c2ccc(Nc3cncnc3)cc12

InChI Key: InChIKey=NCZJJJKTTOBGNN-MNOFBEFESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 303058   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM303058 ((2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1...) Show SMILES CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NC2CCCN(C2=O)c2cc(C)ccc2F)c2ccc(Nc3cncnc3)cc12 |r| Show InChI InChI=1S/C33H33F2N7O4/c1-19-5-7-26(35)29(10-19)41-9-3-4-27(33(41)46)39-32(45)30-11-21(34)15-42(30)31(44)17-40-16-25(20(2)43)24-12-22(6-8-28(24)40)38-23-13-36-18-37-14-23/h5-8,10,12-14,16,18,21,27,30,38H,3-4,9,11,15,17H2,1-2H3,(H,39,45)/t21-,27?,30+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. US Patent					Assay Description Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...				US Patent US10660876 (2020)
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM303058 ((2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1...) Show SMILES CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NC2CCCN(C2=O)c2cc(C)ccc2F)c2ccc(Nc3cncnc3)cc12 |r| Show InChI InChI=1S/C33H33F2N7O4/c1-19-5-7-26(35)29(10-19)41-9-3-4-27(33(41)46)39-32(45)30-11-21(34)15-42(30)31(44)17-40-16-25(20(2)43)24-12-22(6-8-28(24)40)38-23-13-36-18-37-14-23/h5-8,10,12-14,16,18,21,27,30,38H,3-4,9,11,15,17H2,1-2H3,(H,39,45)/t21-,27?,30+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ACHILLION PHARMACEUTICALS, INC. US Patent					Assay Description Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...				US Patent US9598446 (2017) BindingDB Entry DOI: 10.7270/Q2ST7RWF
					More data for this Ligand-Target Pair