BDBM303379 US10138222, Example 104

SMILES: Fc1cc(Cl)c(cc1C(=O)NC1CC1)-c1cnn(c1)-c1cncc(c1)C1CC1

InChI Key: InChIKey=IXKYIPYQCJRSNE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 303379   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase RIPK2 (Homo sapiens (Human))	BDBM303379 (US10138222, Example 104) Show SMILES Fc1cc(Cl)c(cc1C(=O)NC1CC1)-c1cnn(c1)-c1cncc(c1)C1CC1 Show InChI InChI=1S/C21H18ClFN4O/c22-19-7-20(23)18(21(28)26-15-3-4-15)6-17(19)14-9-25-27(11-14)16-5-13(8-24-10-16)12-1-2-12/h5-12,15H,1-4H2,(H,26,28)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...				US Patent US10138222 (2018) BindingDB Entry DOI: 10.7270/Q2RV0QS2
					More data for this Ligand-Target Pair