BDBM303784 2-(10-Chloro-2,5-dioxo-2,5,6,7-tetrahydro-3H-pyrido[3,4-d][2]benzazepin-3-yl)-N-[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]butanamide (Stereoisomer Mixture)::US10138236, Example 2

SMILES: CCC(C(=O)Nc1ccc(cc1)-c1noc(=O)[nH]1)n1cc2c(cc1=O)-c1cc(Cl)ccc1CNC2=O

InChI Key: InChIKey=ISVJPGYUZXHMRW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 303784   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM303784 (2-(10-Chloro-2,5-dioxo-2,5,6,7-tetrahydro-3H-pyrid...) Show SMILES CCC(C(=O)Nc1ccc(cc1)-c1noc(=O)[nH]1)n1cc2c(cc1=O)-c1cc(Cl)ccc1CNC2=O |$;;;;;HN;;;;;;;;;;;;HN;;;;;;;;;;;;;;;;HN;;$| Show InChI InChI=1S/C25H20ClN5O5/c1-2-20(24(34)28-16-7-4-13(5-8-16)22-29-25(35)36-30-22)31-12-19-18(10-21(31)32)17-9-15(26)6-3-14(17)11-27-23(19)33/h3-10,12,20H,2,11H2,1H3,(H,27,33)(H,28,34)(H,29,30,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description o determine the plasma kallikrein inhibition of the substances according to the invention, a biochemical test system is used which utilizes the react...				US Patent US10138236 (2018) BindingDB Entry DOI: 10.7270/Q2445PH4
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM303784 (2-(10-Chloro-2,5-dioxo-2,5,6,7-tetrahydro-3H-pyrid...) Show SMILES CCC(C(=O)Nc1ccc(cc1)-c1noc(=O)[nH]1)n1cc2c(cc1=O)-c1cc(Cl)ccc1CNC2=O |$;;;;;HN;;;;;;;;;;;;HN;;;;;;;;;;;;;;;;HN;;$| Show InChI InChI=1S/C25H20ClN5O5/c1-2-20(24(34)28-16-7-4-13(5-8-16)22-29-25(35)36-30-22)31-12-19-18(10-21(31)32)17-9-15(26)6-3-14(17)11-27-23(19)33/h3-10,12,20H,2,11H2,1H3,(H,27,33)(H,28,34)(H,29,30,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...				US Patent US10138236 (2018) BindingDB Entry DOI: 10.7270/Q2445PH4
					More data for this Ligand-Target Pair