BDBM303912 US10138241, Example 99

SMILES: CN1CC[C@H](C1)c1ccc2ncc(-n3cc(cn3)-c3cc(C(=O)NC4CC4)c(F)cc3C)n2c1

InChI Key: InChIKey=RKNRQFWAWADSNR-GOSISDBHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 303912   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase RIPK2 (Homo sapiens (Human))	BDBM303912 (US10138241, Example 99 | US11130754, Example 99) Show SMILES CN1CC[C@H](C1)c1ccc2ncc(-n3cc(cn3)-c3cc(C(=O)NC4CC4)c(F)cc3C)n2c1 |r| Show InChI InChI=1S/C26H27FN6O/c1-16-9-23(27)22(26(34)30-20-4-5-20)10-21(16)19-11-29-33(15-19)25-12-28-24-6-3-17(14-32(24)25)18-7-8-31(2)13-18/h3,6,9-12,14-15,18,20H,4-5,7-8,13H2,1-2H3,(H,30,34)/t18-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase RIPK2 (Homo sapiens (Human))	BDBM303912 (US10138241, Example 99 | US11130754, Example 99) Show SMILES CN1CC[C@H](C1)c1ccc2ncc(-n3cc(cn3)-c3cc(C(=O)NC4CC4)c(F)cc3C)n2c1 |r| Show InChI InChI=1S/C26H27FN6O/c1-16-9-23(27)22(26(34)30-20-4-5-20)10-21(16)19-11-29-33(15-19)25-12-28-24-6-3-17(14-32(24)25)18-7-8-31(2)13-18/h3,6,9-12,14-15,18,20H,4-5,7-8,13H2,1-2H3,(H,30,34)/t18-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...				US Patent US10138241 (2018) BindingDB Entry DOI: 10.7270/Q2VM4FBZ
					More data for this Ligand-Target Pair