BDBM303914 N-Cyclopropyl-5-{1-[6-(1-ethyl-4-fluoro-piperidin-4-yl)-7-methoxy-imidazo[1,2-a]pyridin-3-yl]-1H-pyrazol-4-yl}-2-fluoro-4-methyl-benzamide::US10138241, Example 101

SMILES: CCN1CCC(F)(CC1)c1cn2c(cnc2cc1OC)-n1cc(cn1)-c1cc(C(=O)NC2CC2)c(F)cc1C

InChI Key: InChIKey=BGBQHJTZPPKKSO-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 303914   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase RIPK2 (Homo sapiens (Human))	BDBM303914 (N-Cyclopropyl-5-{1-[6-(1-ethyl-4-fluoro-piperidin-...) Show SMILES CCN1CCC(F)(CC1)c1cn2c(cnc2cc1OC)-n1cc(cn1)-c1cc(C(=O)NC2CC2)c(F)cc1C Show InChI InChI=1S/C29H32F2N6O2/c1-4-35-9-7-29(31,8-10-35)23-17-36-26(13-25(23)39-3)32-15-27(36)37-16-19(14-33-37)21-12-22(24(30)11-18(21)2)28(38)34-20-5-6-20/h11-17,20H,4-10H2,1-3H3,(H,34,38)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...				US Patent US10138241 (2018) BindingDB Entry DOI: 10.7270/Q2VM4FBZ
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