BDBM30454 hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 4e

SMILES: CC(C)(C)CCN1N2CCCC2(C)C(=O)C(C1=O)C1=Nc2ccc(NS(C)(=O)=O)cc2S(=O)(=O)N1

InChI Key: InChIKey=NWVYWGIBTQILDC-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 30454   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-structural protein 5B (NS5B) (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM30454 (hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 4e) Show SMILES CC(C)(C)CCN1N2CCCC2(C)C(=O)C(C1=O)C1=Nc2ccc(NS(C)(=O)=O)cc2S(=O)(=O)N1 |t:20| Show InChI InChI=1S/C22H31N5O6S2/c1-21(2,3)10-12-26-20(29)17(18(28)22(4)9-6-11-27(22)26)19-23-15-8-7-14(24-34(5,30)31)13-16(15)35(32,33)25-19/h7-8,13,17,24H,6,9-12H2,1-5H3,(H,23,25)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	180	n/a	1.10E+3	n/a	n/a	7.5	28
Anadys Pharmaceuticals					Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...				Bioorg Med Chem Lett 18: 5002-5 (2008) Article DOI: 10.1016/j.bmcl.2008.08.017 BindingDB Entry DOI: 10.7270/Q2XW4H5X
					More data for this Ligand-Target Pair