BDBM304984 3-{4-chloro-3-[(N-methylpyridine-3-sulfonamido)methyl]phenyl}-3-(1-methyl-1H-1,2,3-benzotriazol-5-yl)propanoic acid::US10144731, Example 140

SMILES: CN(Cc1cc(ccc1Cl)C(CC(O)=O)c1ccc2n(C)nnc2c1)S(=O)(=O)c1cccnc1

InChI Key: InChIKey=MFYPHSBKCCZZFC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304984   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
KEAP1/Cullin-3/Microtubule-associated protein tau (Homo sapiens (Human))	BDBM304984 (3-{4-chloro-3-[(N-methylpyridine-3-sulfonamido)met...) Show SMILES CN(Cc1cc(ccc1Cl)C(CC(O)=O)c1ccc2n(C)nnc2c1)S(=O)(=O)c1cccnc1 Show InChI InChI=1S/C23H22ClN5O4S/c1-28(34(32,33)18-4-3-9-25-13-18)14-17-10-15(5-7-20(17)24)19(12-23(30)31)16-6-8-22-21(11-16)26-27-29(22)2/h3-11,13,19H,12,14H2,1-2H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of 5'-TAMRA-labelled NRF2 peptide from human N-terminal His6-tagged KEAP1 Kelch domain (321 to 609 residues) expressed in baculovirus in...				J Med Chem 62: 4683-4702 (2019) Article DOI: 10.1021/acs.jmedchem.9b00279
					More data for this Ligand-Target Pair
Keap1 (aa 321-609) (Homo sapiens (Human))	BDBM304984 (3-{4-chloro-3-[(N-methylpyridine-3-sulfonamido)met...) Show SMILES CN(Cc1cc(ccc1Cl)C(CC(O)=O)c1ccc2n(C)nnc2c1)S(=O)(=O)c1cccnc1 Show InChI InChI=1S/C23H22ClN5O4S/c1-28(34(32,33)18-4-3-9-25-13-18)14-17-10-15(5-7-20(17)24)19(12-23(30)31)16-6-8-22-21(11-16)26-27-29(22)2/h3-11,13,19H,12,14H2,1-2H3,(H,30,31)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Intellectual Property Development Limited; Astex Therapeutics, Ltd US Patent					Assay Description 10-point semi-log dilution curves in DMSO are prepared in 96-well polypropylene plates to 100× final assay concentration. Compound curves are then di...				US Patent US10144731 (2018) BindingDB Entry DOI: 10.7270/Q25X2C17
					More data for this Ligand-Target Pair