BDBM306186 US10144742, Compound I-348

SMILES: Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCC1COC1)C(=O)NCCCc1ncc[nH]1

InChI Key: InChIKey=SMXJTYSAEWSGGL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306186   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM306186 (US10144742, Compound I-348) Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCC1COC1)C(=O)NCCCc1ncc[nH]1 Show InChI InChI=1S/C25H24FN5O3/c26-19-6-3-17(4-7-19)23-25(34-15-16-13-33-14-16)31-20-8-5-18(12-21(20)30-23)24(32)29-9-1-2-22-27-10-11-28-22/h3-8,10-12,16H,1-2,9,13-15H2,(H,27,28)(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. US Patent					Assay Description To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...				US Patent US10144742 (2018) BindingDB Entry DOI: 10.7270/Q2NV9M91
					More data for this Ligand-Target Pair