BDBM306235 US10144742, Compound I-397

SMILES: Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(Cl)c(Cl)c1)C(=O)NCCCc1ncc[nH]1

InChI Key: InChIKey=PEKSPRSEKGKYAO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306235   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM306235 (US10144742, Compound I-397) Show SMILES Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(Cl)c(Cl)c1)C(=O)NCCCc1ncc[nH]1 Show InChI InChI=1S/C27H20Cl2FN5O/c28-20-9-5-17(14-21(20)29)26-25(16-3-7-19(30)8-4-16)34-22-10-6-18(15-23(22)35-26)27(36)33-11-1-2-24-31-12-13-32-24/h3-10,12-15H,1-2,11H2,(H,31,32)(H,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. US Patent					Assay Description To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...				US Patent US10144742 (2018) BindingDB Entry DOI: 10.7270/Q2NV9M91
					More data for this Ligand-Target Pair