BDBM306277 US10144742, Compound I-439

SMILES: Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCc1ccccc1)C(=O)NCCCc1ncc[nH]1

InChI Key: InChIKey=FBLBLQIILMLXEX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM306277 (US10144742, Compound I-439) Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCc1ccccc1)C(=O)NCCCc1ncc[nH]1 Show InChI InChI=1S/C28H24FN5O2/c29-22-11-8-20(9-12-22)26-28(36-18-19-5-2-1-3-6-19)34-23-13-10-21(17-24(23)33-26)27(35)32-14-4-7-25-30-15-16-31-25/h1-3,5-6,8-13,15-17H,4,7,14,18H2,(H,30,31)(H,32,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. US Patent					Assay Description To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...				US Patent US10144742 (2018) BindingDB Entry DOI: 10.7270/Q2NV9M91
					More data for this Ligand-Target Pair