BDBM306278 US10144742, Compound I-440

SMILES: CCOc1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1

InChI Key: InChIKey=VRYNVTLMFQYJFS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM306278 (US10144742, Compound I-440) Show SMILES CCOc1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1 Show InChI InChI=1S/C23H22FN5O2/c1-2-31-23-21(15-5-8-17(24)9-6-15)28-19-14-16(7-10-18(19)29-23)22(30)27-11-3-4-20-25-12-13-26-20/h5-10,12-14H,2-4,11H2,1H3,(H,25,26)(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. US Patent					Assay Description To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...				US Patent US10144742 (2018) BindingDB Entry DOI: 10.7270/Q2NV9M91
					More data for this Ligand-Target Pair