BDBM306300 US10144742, Compound I-462

SMILES: Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCC#C)C(=O)NCCCc1ncc[nH]1

InChI Key: InChIKey=HOTLSNLDKRSBIQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306300   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM306300 (US10144742, Compound I-462) Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCC#C)C(=O)NCCCc1ncc[nH]1 Show InChI InChI=1S/C24H20FN5O2/c1-2-14-32-24-22(16-5-8-18(25)9-6-16)29-20-15-17(7-10-19(20)30-24)23(31)28-11-3-4-21-26-12-13-27-21/h1,5-10,12-13,15H,3-4,11,14H2,(H,26,27)(H,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. US Patent					Assay Description To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...				US Patent US10144742 (2018) BindingDB Entry DOI: 10.7270/Q2NV9M91
					More data for this Ligand-Target Pair