BDBM306497 (1R,8S)-N-[(6-amino-2,4- dimethylpyridin-3-yl)-methyl]-12- (4-chloro-2-cyanophenyl)-15- oxatetracyclo[6.6.1.02,7.09,14] pentadeca-2,4,6,9,11,13- hexaene-4-carboxamide::US10144746, Compound 139

SMILES: Cc1cc(N)nc(C)c1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-c1ccc(Cl)cc1C#N

InChI Key: InChIKey=IZTZNFYCAUXHCR-URLMMPGGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306497   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306497 ((1R,8S)-N-[(6-amino-2,4- dimethylpyridin-3-yl)-met...) Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-c1ccc(Cl)cc1C#N |r| Show InChI InChI=1S/C30H23ClN4O2/c1-15-9-27(33)35-16(2)26(15)14-34-30(36)18-4-7-23-25(12-18)29-24-11-17(3-6-22(24)28(23)37-29)21-8-5-20(31)10-19(21)13-32/h3-12,28-29H,14H2,1-2H3,(H2,33,35)(H,34,36)/t28-,29+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.02	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
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